ABSTRACT
MeAN administration (40mg/kg body wt/day (i.e. 1/5 of LD50) resulted in increased levels of lipid peroxidation products, conjugated dienes and lipofuscin-like substances in rat liver. Significant decrease in GSH and a decreased activity of hepatic SOD, CAT and GPx were observed. There was also an increase in glutathione S-transferase and G6PD activities, decreased plasma ceruloplasmin and vitamin C implying oxidative stress caused by MeAN.
Subject(s)
Animals , Antioxidants/metabolism , Glutathione/metabolism , Lipid Peroxidation/drug effects , Lipofuscin/metabolism , Liver/drug effects , Male , Methacrylates/toxicity , Nitriles/toxicity , Oxidative Stress/drug effects , Rats , Rats, WistarABSTRACT
Administration of tarakeswara rasa--an ayurvedic drug--to alloxan induced diabetic rats resulted in a significant decrease in the blood glucose. Its antidiabetic effect was also evident from the tissue parameters estimated. The drug administration to diabetic rats also resulted in the reduction of cholesterol, triglyceride and phospholipid content.